Nathalie Dom
History
- Member for
- 5 years 3 weeks
Professional information
- Own research projects
- Participation in other projects
- Position in the lab
- PhD student
- Curriculum Vitae
I studied Biomedical Sciences at the University of Antwerp. After finishing my master thesis - “Evaluation of ethynylestradiol as neuro-endocrine disruptor in zebrafish” - at EBT, I graduated in 2005. Additionally, I graduaded as a Master in Environmental Sciences in 2006.
After my studies, I started as a PhD student at EBT. Here, the possible contribution of a transcriptomics approach to the QSAR methodology is investigated. The aim of my research is to evaluate whether biological ("omics") data can support MOA classification in order to improve the accuracy of the QSAR estimates for environmental hazard endpoints. Toxicogenomics, combined with physiological parameters, is applied in order to elucidate MOA of different structural analogues with presumed similar MOAs. The water flea (Daphnia magna) is being used as test organism.This research is conducted within the framework of the European OSIRIS project(GOCE-CT-2007-037017) and is funded by the IWT Flanders.
- Selected publications
Nathalie Dom, Ingrid Nobels, Dries Knapen, Ronny Blust (2011). Bacterial gene profiling assay applied as an alternative method for mode of action classification: pilot study using chlorinated anilines. Environmental Toxicology and Chemistry 30(5), 1059-1068
Nathalie Dom, Dries Knapen, Donald Benoot, Ingrid Nobels, Ronny Blust (2010). Aquatic multi-species acute toxicity of (chlorinated) anilines: Experimental versus predicted data. Chemosphere 81(2), 177-186.
Tine Vandenbrouck, Oliver A.H. Jones, Nathalie Dom, Julian L. Griffin, Wim De Coen (2010). Mixtures of similarly acting compounds in Daphnia magna: From gene to metabolite and beyond. Environment International 36, 254-268.
Kilian E.C. Smith, Nathalie Dom, Ronny Blust, Philipp Mayer (2010). Controlling and maintaining exposure of hydrophobic organic compounds in aquatic toxicity tests by passive dosing. Aquatic Toxicology 98, 15-24.
- Selected presentations
Nathalie Dom, Dries Knapen, Ronny Blust. Transcriptomics to discriminate among different modes of chemical stress in Daphnia magna. SETAC North America. 31st Annual meeting, Portland, Oregon, USA, November 7-11, 2010 - platform presentation
Nathalie Dom, Dries Knapen, Ronny Blust. Daphnia magna exposed to four aniline derivatives: transcriptomics in combination with the assessment of (sub)organismal effects as a biology-based alternative to categorize chemicals according to their MOA. Beltox annual scientific meeting, Louvain-la-Neuve, Belgium, November 25, 2010 - poster presentation
Nathalie Dom, Melissa Penninck, Wim De Coen, Dries Knapen, Ronny Blust. Acute versus chronic toxicity of a group of structural analogues in Daphnia magna. SETAC Europe, 20th Annual meeting, Seville, May 23-27, 2010 - platform presentation
Nathalie Dom, Amy Filby, Dries Knapen, Donald Benoot, Charles Tyler, Ronny Blust. Investigating the use of zebrafish embryos as an alternative for the zebrafish acute toxicity test: A case study using chlorinated anilines. SETAC Europe, 20th Annual meeting, Seville, Spain, May 23-27, 2010 - poster presentation
Melissa Penninck, Nathalie Dom, Andrea Vlaeminck, Dries Knapen, Ronny Blust. Validation of a QSAR approach to predict toxicity across a large diversity of organic compounds. SETAC Europe, 20th Annual meeting, Seville, May 23-27, 2010 - poster presentation
Nathalie Dom, Tine Vandenbrouck, Dries Knapen, Ronny Blust. Toxicogenomics used as a biology-based alternative method to investigate the mode of action of structural analogues. Daphnia genomics consortium, Leuven, Belgium, March 26-30, 2010 - poster presentation
Nathalie Dom, Dries Knapen, Wim De Coen, Ronny Blust. Toxicity prediction of chloro-substituted anilines versus acute and chronic toxicity testing in Daphnia magna. 26th ESCPB congress, Innsbruck, Austria, September 6-10, 2009; Comparative Biochemistry and Physiology (2009), Part A 154, S23–S27 - platform presentation
Nathalie Dom, Ingrid Nobels, Donald Benoot, Tine Vandenbrouck, Mieke Jansen, Dries Knapen, Wim De Coen, Ronny Blust. Can toxicogenomics support QSAR MOA approaches? A selected case study using (chlorinated) anilines. SETAC Europe 19th Annual meeting, Goteborg, June 1-4, 2009 - platform presentation
Killian EC Smith, Nathalie Dom, Ronny Blust, Philipp Mayer. Passive dosing for establishing constant freely dissolved concentrations of hydrophobic compounds. SETAC Europe, 19th Annual meeting, Goteborg, June 1-4, 2009 - platform presentation
Nathalie Dom, Tine Vandenbrouck, Dries Knapen, Ronny Blust, Johan Robbens, Wim De Coen. Practical application of genomics in support of QSAR development. SETAC North America, 29th Annual Meeting, Tampa, USA, November 16-20, 2008 - poster presentation
Nathalie Dom, Tine Vandenbrouck, Dries Knapen, Andrew Worth, Ronny Blust, Wim De Coen. Toxicogenomics support for QSAR development: a case study using Daphnia magna. SETAC Europe, 18th Annual Meeting, Warsaw, Poland. May 25-29, 2008 - poster presentation