caroline vanparys
History
- Member for
- 5 years 41 weeks
Professional information
- Own research projects
- Position in the lab
- Post-doc fellow
- Curriculum Vitae
I studied Biomedical Sciences at the University of Antwerp. I chose for the direction of environmental toxicology with the thesis: the great tit (Parus major) as biomonitor of heavy metal contamination. After finishing my thesis, I decided to leave environmental monitoring with living species for developing in vitro assays that in the end would reduce animal testing. So in 2004, I started my PhD at the Laboratory of Ecophysiology, Biochemistry and Toxicology at the University of Antwerp with Prof. Dr. Wim De Coen as promoter. I first optimized a flow cytometric cell cycle analysis test for rapid screening of estrogenicity in MCF-7 breast cancer cells. Although receptor-mediated toxicity is an important mechanism of endocrine disruption, interest in the more complex non-receptor mediated mechanisms directed to the main subject of my PhD: The development of a H295R-specific custom array as a promising new in vitro model for screening of endocrine disruptive chemicals. This research project is funded by the IWT
- Selected publications
Vanparys C., Maras M., Lenjou M., Robbens J., Van Bockstaele D., Blust R., De Coen W. (2006) Flow cytometric cell cycle analysis allows for rapid screening of estrogenicity in MCF-7 breast cancer cells. Toxicology In Vitro 20: 1238-1248.
- Selected presentations
Vanparys C., Dauwe T., Van Campenhout K., Bervoets L., De Coen W., Blust R., Eens M. Metal accumulation in relation to metallothioneines (MTs) and aminolevulinic acid dehydratase (ALAd) in great tits (Parus major) along a pollution gradient. SETAC Europe 14th Annual Meeting, Prague, 18-22 April 2004.
Vanparys C., Maras M., Lenjou M., Del Favero J., Robbens J., Van Bockstaele D., Blust R., De Coen W. Flow cytometry as a tool to study effects of xeno-estrogens on cell cycle kinetics in MCF-7 breast cancer cells. SETAC Europe 15th Annual Meeting, Lille (France) 22-26 May 2005.
Vanparys C., Maras M., Naudts B., Robbens J., Vanhummelen P., Witters E., Van Onckelen H., Esmans E., Blust R., De Coen W. The H295R adrenocortical cell line as alternative in vitro system for screening of endocrine disruptors: a microarray based approach. 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, 21-25 August 2005.
Vanparys C., Maras M., van der Ven K., Robbens J., Blust R., De Coen W. Development of a custom made microarray as an alternative screening tool for endocrine disruptors. ecopa Science Initiative (eSI) meeting, Alicante, 28-29 September 2006.
Vanparys C., Maras M., van der Ven K., Robbens J., Blust R., De Coen W. Development of a custom made microarray as an alternative screening tool for endocrine disruptors. 7th Annual ecopa Workshop: REACH for help: Science back up, Brussels, 25-26 November 2006.
- Awards
Award for an Outstanding Scientific Communication at the BELTOX Annual Meeting, Namur, 2007