molecular mechanisms

This research addresses some key consequences, effects and differences of the short-term and long-term uptake and accumulation of an essential (Zn) and a non-essential (Cd) metal in the fresh water fi

In this project we’ll try to examine if endocrine disrupting compounds (EDCs) are capable off disrupting pancreas, liver and adipocyt function, if they can cause changes in insulin, glucagon and leptin levels and if they can induce molecular mechanisms that could be associated with certain metabolic diseases such as diabetes, obesity and/or cardiovascular diseases. A limited list of endocrine disrupting chemicals, known as pollutants, will be studied. This project attempts to show that these chemicals disturb energy reservoirs of cells, specifically by intervening with glucose and/or lipid metabolism. Special attention will be directed to the elucidation of the mechanisms of action that underlie these disruption.