New EU regulations raise the need for fast screening methods that can be used for the characterization of chemicals. The prediction of the mechanisms of toxicity of a compound is crucial for its characterization.
Molecular and Cellular Toxicology
Effect of temperature on metal toxicity to zebrafish: frome gene to organismal responses
During recent years ecotoxicology has been an emerging field and its experimental focus has been expanded from using mainly chemical stressors (e.g. cadmium) to assessing the effects of natural or non-chemical stressors (e.g.
Alternative methods for MOA classification in support of QSAR development
Aquatic toxicity information is essential in environmental risk assessment to determine the potential hazards of risks of new and existing chemicals.
Epigenetic and maternal effects of toxicants with different MOA in zebrafish (Danio rerio)
We all know that since the beginning of the 20th century, the industry is the driving force behind the introduction of new chemicals.
Characterization of toxicological effects on the energy metabolism after exposure to endocrine disrupting compounds
In this project we’ll try to examine if endocrine disrupting compounds (EDCs) are capable off disrupting pancreas, liver and adipocyt function, if they can cause changes in insulin, glucagon and leptin levels and if they can induce molecular mechanisms that could be associated with certain metabolic diseases such as diabetes, obesity and/or cardiovascular diseases. A limited list of endocrine disrupting chemicals, known as pollutants, will be studied. This project attempts to show that these chemicals disturb energy reservoirs of cells, specifically by intervening with glucose and/or lipid metabolism. Special attention will be directed to the elucidation of the mechanisms of action that underlie these disruption.
