The CEQ 8000 Genetic analysis system is a fully automated system, capable of determining the base sequence and fragment length of DNA samples that have been prepared with Beckman Coulter dye-labeled reagents. Four color, dye-labeled terminator chemistry kits (e.g. CEQTM Dye terminator cycle sequence kit) are used to process samples for base sequence analysis. Generation of samples for fragment length analysis is performed using dye-labeled primers. The CEQ 8000 system accepts up to 96 four-color samples in a microplate. Each row of eight samples (sample set), containing labeled DNA fragments, is automatically denatured and then separated by capillary electrophoresis. Detection is by laser-induced fluorescence in four spectral channels. The four-channel raw data sets generated by each of the eight capilaries are automatically processed to produce high quality base sequences or fragment lists after separation. Raw and analyzed data are stored in a database and may also be exported in file formats compatible with common analysis applications.
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